Pharmacologic Substance
ganciclovir Audio
[ gan-sy-kloh-veer ]
Brand Names:
Cytovene; Zirgan
Effect:
Decreased DNA Replication; Decreased Protein Synthesis
May Prevent:
Cytomegalovirus Infections
May Treat:
AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to ganciclovir:
  • 9-(1,3-dihydroxy-2-propoxy)methylguanine; acyclovir analog which inhibits DNA replication of CMV and therefore has efficacy against AIDS-related oculopathy.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An antiviral agent used to prevent or treat cytomegalovirus infections that may occur when the body's immune system is suppressed. In gene therapy, ganciclovir is used with an altered herpes simplex virus-1 gene to kill advanced melanoma cells and brain tumor cells.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • (dihydroxypropoxymethylguanine) Family of acyclovir analogs with antiviral efficacy against herpes simplex and cytomegalovirus, a cause of AIDS-related blindness.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.