Cell Component
lewy body
Subclass of:
Inclusion Bodies
Definitions related to lewy bodies:
  • (lewy body) Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
  • (lewy body) Filamentous cytoplasmic inclusions of unknown pathogenesis in some brain areas; found in association with several disabling and dementing neurodegenerative disorders.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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