Pharmacologic Substance
nafoxidine
Subclass of:
Pyrrolidines
Definitions related to nafoxidine:
  • A triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An estrogen antagonist that has been used in the treatment of breast cancer.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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