Organic Chemical
naloxone Audio
nal·ox·one [ nuh-lok-sohn, nal-uh k-sohn ]
Brand Names:
Bunavail; Evzio; Kloxxado; Narcan; Suboxone; Zubsolv
Effect:
Central Nervous System Stimulation; Increased Blood Pressure; Increased Medullary Respiratory Drive
May Treat:
Opioid-Related Disorders; Respiration Disorders; Shock, Septic
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to naloxone:
  • A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A substance that is being studied as a treatment for constipation caused by narcotic medications. It belongs to the family of drugs called narcotic antagonists.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A thebaine derivate with competitive opioid antagonistic properties. Naloxone reverses the effects of opioid analgesics by binding to the opioid receptors in the CNS, and inhibiting the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Specific opiate antagonist with no agonist activity, a competitive antagonist at mu, delta, and kappa opioid receptors.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.