Pharmacologic Substance
nelarabine Audio
[ neh-lar-uh-been ]
Brand Names:
Arranon
Effect:
Decreased DNA Integrity; Decreased DNA Replication; Increased Cellular Death
May Treat:
Leukemia, T-Cell
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to nelarabine:
  • A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.