Neoplastic Process
neurofibrosarcoma
Subclass of:
neurofibroma; Fibrosarcoma
Definitions related to neurofibrosarcoma:
  • A form of malignant cancer of the connective tissue surrounding nerves. Given its origin and behavior, it is classified as a sarcoma.
    Human Phenotype Ontology (HPO)
    The Human Phenotype Ontology Project, 2021
  • A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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