Physiologic Function
neutrophil activation
neu·tro·phil ac·tiva·tion [ noo-truh-fil, nyoo- ak-tuh-vey-shun ]
Definitions related to neutrophil activation:
  • Neutrophil Activation involves cell interaction and cell signaling mechanisms that recognize or respond to the presence of foreign antigen and that stimulate phagocytosis, degranulation, or generation of reactive oxygen products by neutrophils to destroy invading pathogens or to induce acute inflammatory reactions.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
    Gene Ontology Dictionary
    Gene Ontology Consortium, 2021
  • The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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