Pharmacologic Substance
nisoldipine
Brand Names:
Sular
Effect:
Coronary Arterial Vasodilation; Decreased Blood Pressure
May Treat:
Angina Pectoris, Variant; Hypertension
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to nisoldipine:
  • A dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. It is also effective in patients with cardiac failure and angina.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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