Pharmacologic Substance
nitracrine
Subclass of:
Aminoacridines
Definitions related to nitracrine:
  • Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An acridine derivative with potential cytostatic and antitumor activities. Although the exact mechanism of action has not been fully elucidated, nitracrine induces the unwinding of supercoiled DNA and binds to the DNA through intercalation, forming drug-DNA adducts and DNA interstrand crosslinks. This inhibits RNA synthesis, protein production, cell growth, DNA replication and cell proliferation; altogether, this may promote apoptosis. Since cancer cells have increased metabolism and proliferate at an increased rate, nitracrine may induce tumor cell apoptosis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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