Pharmacologic Substance
nortriptyline Audio
[ nawr-trip-tuh-leen ]
Brand Names:
Pamelor
Effect:
Decreased Serotonin Degradation; Increased Central Nervous System Norepinephrine Activity
May Treat:
Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Depressive Disorder; Enuresis; Pain
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to nortriptyline:
  • A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Tricyclic antidepressant of the dibenzocycloheptadiene class used to treat symptoms of depression and to relieve chronic, severe pain.
    CRISP Thesaurus
    National Institutes of Health, 2006
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.