Pharmacologic Substance
ondansetron
Brand Names:
Zofran; Zuplenz
Effect:
Decreased Central Nervous System Serotonin Activity; Decreased Peripheral Nervous System Serotonin Activity; Emesis Suppression
May Prevent:
Postoperative Nausea and Vomiting
May Treat:
Alcoholism
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to ondansetron:
  • A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Competitive serotonin type 3 receptor antagonist used in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs; also has anxiolytic and neuroleptic properties.
    CRISP Thesaurus
    National Institutes of Health, 2006
  • The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Ondansetron is a type of serotonin receptor antagonist and a type of antiemetic.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.