Pharmacologic Substance
orphenadrine
Brand Names:
Norgesic; Orphengesic
Effect:
Centrally-mediated Muscle Relaxation; Decreased CNS Organized Electrical Activity; Striated Muscle Metabolic Alteration
May Treat:
Muscle Cramp; Muscle Rigidity; Myositis; Pain; Spasm; Tetanus
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to orphenadrine:
  • A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block muscarinic acetylcholine receptors as well as N-methyl-D-aspartate (NMDA) receptors in the central nervous system (CNS). This may interfere with the transmission of nerve impulses from the spinal cord to the muscles and may help relax muscles. In addition, orphenadrine exerts antagonistic effects on histamine H1 receptors.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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