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Images:
  • Oxaliplatin image from Wikimedia
  • Oxaliplatin image from Wikimedia
Pharmacologic Substance
oxaliplatin Audio
[ ok-sa-lih-pla-tin ]
Effect:
Decreased DNA Integrity; Decreased DNA Replication
May Treat:
Colorectal Neoplasms; Ovarian Neoplasms; Testicular Neoplasms; Urinary Bladder Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to oxaliplatin:
  • A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.

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