Antibiotic
rebeccamycin Audio
[ reh-beh-kuh-my-sin ]
Definitions related to rebeccamycin:
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antineoplastic antibiotics.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • An indolocarbazole glycoside antineoplastic antibiotic isolated from the bacterium Saccharothrix aerocolonigenes. Rebeccamycin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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