Pharmacologic Substance
sorivudine Audio
[ sor-ih-vyoo-deen ]
Definitions related to sorivudine:
  • A synthetic thymidine analogue with potent antiviral activity against herpes simplex and varicella zoster viruses. Sorivudine is phosphorylated into triphosphate form within the cells; this metabolite interferes with viral DNA replication by inhibiting DNA polymerase activity without been incorporated into elongating viral DNA. Due to the dangerous effects of drug-drug interactions via its metabolite, sorivudine has been removed from the market.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An antiviral drug that is being studied as a treatment for herpesvirus. It belongs to the family of drugs called nucleic acid synthesis inhibitors.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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