Pharmacologic Substance
spironolactone Audio
spi·ro·no·lac·tone [ spahy-ruh-noh-lak-tohn, spahy-roh-, -ron-uh- ]
Brand Names:
Aldactazide; Aldactone; Cardalis; Carospir
Effect:
Arterial Vasodilation; Decreased Blood Pressure; Decreased Distal Tubule H+ Excretion; Decreased Distal Tubule K+ Excretion; Increased Distal Tubule Na+ Excretion
May Treat:
Ascites; Edema; Heart Failure; Hirsutism; Hyperaldosteronism; Hypertension; Hypokalemia
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to spironolactone:
  • A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities.Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules; used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis; its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.