Pharmacologic Substance
tacrolimus Audio
[ tak-roh-lih-mus ]
Brand Names:
Astagraf; Envarsus; Prograf; Protopic
Effect:
Cellular Growth Phase Arrest; Decreased Cytokine Production; Decreased T Lymphocyte Production
May Prevent:
Graft vs Host Disease
May Treat:
Dermatitis, Atopic; Graft vs Host Disease
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to tacrolimus:
  • A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.