Pharmacologic Substance
tadalafil Audio
[ tuh-da-luh-fil ]
Brand Names:
Adcirca; Alyq; Cialis
Effect:
Penile Venous Vasodilation; Pulmonary Venous Vasodilation
May Treat:
Hypertension, Pulmonary; Impotence, Vasculogenic
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to tadalafil:
  • A carboline derivative and PHOSPHODIESTERASE 5 INHIBITOR that is used primarily to treat ERECTILE DYSFUNCTION; BENIGN PROSTATIC HYPERPLASIA and PRIMARY PULMONARY HYPERTENSION.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A drug used to treat erectile dysfunction. It is also being studied in the treatment of sexual problems in patients treated with radiation or surgery for prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase type 5 (PDE5) inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.