Pharmacologic Substance
tiotropium bromide
Effect:
Bronchodilation; Decreased Parasympathetic Acetylcholine Activity
May Treat:
Bronchitis, Chronic; Pulmonary Emphysema
Definitions related to tiotropium bromide:
  • A scopolamine derivative and CHOLINERGIC ANTAGONIST that functions as a BRONCHODILATOR AGENT. It is used in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • The bromide salt form of tiotropium, a quaternary ammonium derivative of atropine and a muscarinic receptor antagonist, with bronchodilating activity. Although it does not display selectivity for specific muscarinic receptors, on topical application, tiotropium bromide acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands, preventing smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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