Pharmacologic Substance
tolbutamide Audio
tol·bu·ta·mide [ tol-byoo-tuh-mahyd ]
Effect:
Decreased Glycolysis; Increased Glucose Transport into Cells; Increased Insulin Secretion
May Treat:
Diabetes Mellitus, Type 2
Definitions related to tolbutamide:
  • A short-acting, first-generation sulfonylurea with hypoglycemic activity. Compared to second-generation sulfonylureas, tolbutamide is more likely to cause adverse effects, such as jaundice. This agent is rapidly metabolized by CYPC29.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Sulfonylurea compound used as a hypoglycemic in the treatment of noninsulin dependent diabetes mellitus.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.