Pharmacologic Substance
topotecan
Brand Names:
Hycamtin
Effect:
Decreased DNA Replication
May Treat:
Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Ovarian Neoplasms; Small Cell Lung Carcinoma; Uterine Cervical Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to topotecan:
  • A drug used to treat certain types of ovarian cancer, lung cancer, and cervical cancer. Topotecan is a type of topoisomerase inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • Antineoplastic drug which acts as a DNA topoisomerase inhibitor.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.