Pharmacologic Substance
trabectedin Audio
[ truh-bek-teh-din ]
Brand Names:
Yondelis
Effect:
Decreased DNA Integrity
May Treat:
Leiomyosarcoma; Liposarcoma
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to trabectedin:
  • A complex structure that includes isoquinolines joined by a cyclic ester; it is a DNA-binding agent and guanine N2 alkylator derived from the marine tunicate, Ecteinascidia turbinata. Trabectedin is used for the treatment of advanced soft-tissue SARCOMA, after failure of ANTHRACYCLINES or IFOSFAMIDE drug therapy.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A substance that comes from a type of sea squirt and is being studied in the treatment of cancer. It binds to DNA and causes breaks in the DNA. It also blocks the ability of the cell to repair the DNA damage, and may cause cancer cells to die. Trabectedin is also made in the laboratory. It is a type of DNA excision repair inhibitor.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinata with potential antineoplastic activity. Binding to the minor groove of DNA, trabectedin interferes with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks and blocks the cell cycle in the G2 phase.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
Try this search on: Farlex, Merriam-Webster, Oxford Dictionary, or Wordnik

This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.