Pharmacologic Substance
tranexamic acid
Brand Names:
Cyklokapron; Lysteda
Effect:
Decreased Fibrinolysis
May Prevent:
Oral Hemorrhage
May Treat:
Blood Coagulation Disorders, Inherited; Subarachnoid Hemorrhage
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to tranexamic acid:
  • A synthetic derivative of the amino acid lysine with antifibrinolytic activity. With strong affinity for the five lysine-binding sites of plasminogen, tranexamic acid competitively inhibits the activation of plasminogen to plasmin, resulting in inhibition of fibrinolysis; at higher concentrations, this agent noncompetitively inhibits plasmin. This agent has a longer half-life, is approximately ten times more potent, and is less toxic than aminocaproic acid, which possesses similar mechanisms of action.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Antifibrinolytic hemostatic used in severe hemorrhage.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.