Pharmacologic Substance
trimetrexate glucuronate Audio
[ try-meh-trek-sayt gloo-kyoo-roh-nayt ]
Effect:
Decreased DNA Replication; Decreased Protein Synthesis; Decreased RNA Replication
May Treat:
Pneumonia, Pneumocystis
More Information:
ChemID; DailyMed; DrugInfo; PDR
Definitions related to trimetrexate glucuronate:
  • A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
  • A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.