Pharmacologic Substance
troxacitabine Audio
[ trok-suh-sy-tuh-been ]
Definitions related to troxacitabine:
  • A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A drug being studied for use as an anticancer agent.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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