Pharmacologic Substance
verapamil Audio
ve·ra·pam·il [ veer-uh-pam-uhl, ver- ]
Brand Names:
Calan; Isoptin; Tarka; Verelan
Effect:
Coronary Arterial Vasodilation; Decreased Blood Pressure; Negative Chronotropy
May Treat:
Angina Pectoris, Variant; Atrial Fibrillation; Atrial Flutter; Hypertension; Myocardial Infarction; Tachycardia, Supraventricular
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to verapamil:
  • A calcium channel blocker that is a class IV anti-arrhythmia agent.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • Calcium channel blocker that dilates coronary arteries and decreases myocardial oxygen demand.
    CRISP Thesaurus
    National Institutes of Health, 2006
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.