Pharmacologic Substance
vinorelbine
Brand Names:
Navelbine
Effect:
Cellular Growth Phase Arrest; Decreased Mitosis; Increased Cellular Death
May Treat:
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Hodgkin Disease; Ovarian Neoplasms
More Information:
ChemID; DrugBank; DailyMed; DrugInfo; PDR
Definitions related to vinorelbine:
  • A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • A vinca alkaloid related to VINBLASTINE that is used as a first-line treatment for NON-SMALL CELL LUNG CANCER, or for advanced or metastatic BREAST CANCER refractory to treatment with ANTHRACYCLINES.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.
    NCI Dictionary of Cancer Terms
    U.S. National Cancer Institute, 2021
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This content should not be used in place of medically-reviewed decision support reference material or professional medical advice. Some terms may have alternate or updated definitions not reflected in this set. The definitions on this page should not be considered complete or up to date.