Biologically Active Substance
zinostatin
Subclass of:
Enediynes
Definitions related to zinostatin:
  • An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)
    NCI Thesaurus
    U.S. National Cancer Institute, 2021
  • An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
    NLM Medical Subject Headings
    U.S. National Library of Medicine, 2021
  • (neocarzinostatin) Antitumor protein possessing a regulatory function on the metabolism of DNA; also a potent cytostatic agent active against gram-positive bacteria.
    CRISP Thesaurus
    National Institutes of Health, 2006
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