Antibiotic
Echinomycin
A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis. (NCI04)
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A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus. Echinomycin intercalates into DNA at two locations ...
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Oct 1, 2005 ... One of the most potent compounds identified, echinomycin (NSC-13502), a small-molecule known to bind DNA in a sequence-specific fashion, was ...
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May 7, 2020 ... Echinomycin is a novel bifunctional intercalating agent derived from Streptomyces echinatus. A phase II clinical trial of echinomycin in ...
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Feb 10, 2017 ... Echinomycin treatment reduces aGVHD and preserves GVL effect via increasing donor Treg development and diminishing alloantigen-specific Th17 and ...
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In vitro activities (MICs and MBCs) of oxacillin, vancomycin and echinomycin against 18 isolates of methicillin-susceptible S. aureus (MSSA) and 118 ...
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One of the most potent compounds identified, echinomycin (NSC-13502), a small-molecule known to bind DNA in a sequence-specific fashion, was further ...
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Feb 16, 2016 ... There is a need for effective drugs in the prevention and treatment of heterotopic ossifications (HO) after fractures. Echinomycin has been ...
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Dec 20, 1974 ... The interaction between echinomycin and circular DNA or sonicated rod-like DNA fragments shows that this antibiotic binds by a bifunctional ...
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Echinomycin is a natural product found in Streptomycetaceae, Streptomyces griseovariabilis, and other organisms with data available.
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Jul 26, 2017 ... Echinomycin is a cyclic peptide belonging to a family of quinoxaline antibiotics isolated from Streptomyces echinatus.