Antibiotic
Spectinomycin
An aminocyclitol aminoglycoside antibiotic derived from Streptomyces spectabilis with bacteriostatic activity. Spectinomycin binds to the bacterial 30S ribosomal subunit. As a result, this agent interferes with the initiation of protein synthesis and with proper protein elongation. This eventually...
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Brand Names:
SpectoGard
Effect:
Decreased Protein Synthesis
May Prevent:
May Treat:
Group:
Aminoglycosides; Dioxanes; Heterocyclic Compounds, 3-Ring
Mechanism:
Protein Synthesis Inhibitors
More Information:
Merck Manuals
Spectinomycin is a bacteriostatic antibiotic chemically related to the aminoglycosides. Spectinomycin binds to the 30S subunit of the ribosome, thus inhibiting bacterial protein synthesis. Its...
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Jul 10, 2013 ... Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains ...
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CDC and the Food and Drug Administration are working with Pfizer to make spectinomycin available again in the United States and will update this information as ...
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Jun 13, 2005 ... Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis.
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Spectinomycin is a pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat ...
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Spectinomycin is a broad spectrum antibiotic with moderate activity against both gram-positive and gram-negative bacteria. Many gram-positive bacteria, such as ...
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Spectinomycin is an aminocyclitol antibiotic which inhibits bacterial protein biosynthesis by reversibly binding to the 30S ribosomal subunit. Resistance to ...
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Mar 19, 2013 ... The analysis of methicillin-resistant Staphylococcus aureus (MRSA) CC398 from cases of bovine mastitis showed that all spectinomycin-resistant ...
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Although spectinomycin is chemically dissimilar to the aminoglycoside streptomycin, both drugs can be adenylated by enzymes of the ANT(3สบ)(9) [also called ANT( ...
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Spectinomycin is an aminocyclitol antibiotic, which shares similar features with an aminoglycoside. However, it differs in that it does not contain amino sugars ...
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Jan 27, 2021 ... Spectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or ...