Antibiotic
Streptozocin
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes...
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Brand Names:
Zanosar
Effect:
Decreased DNA Integrity; Decreased Protein Modification; Decreased RNA Integrity
May Treat:
Group:
Aminoglycosides; Nitrosourea Compounds
Mechanism:
Alkylating Activity; Nucleic Acid Synthesis Inhibitors
More Information:
Medscape
Zanosar (streptozocin) dosing, indications, interactions, adverse effects, and more.
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Jul 15, 2013 ... Streptozocin can cause a severe decrease in the number of blood cells in your bone marrow. This may cause certain symptoms and may increase the ...
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Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated ...
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Feb 1, 2022 ... Along with their needed effects, medicines like streptozocin can sometimes cause unwanted effects such as kidney problems and other side ...
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Streptozocin is a type of chemotherapy drug called a nitrosourea. It works by sticking to one of the DNA strands of the cancer cell so the cell can't divide ...
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A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross- ...
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Feb 20, 1992 ... Abstract Background. The combination of streptozocin and fluorouracil has become the standard therapy for advanced islet-cell carcinoma.
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Streptozocin is an N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in ...
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Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. J Clin Oncol.
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streptozocin (Rx) ; Mechanism of Action. Nitrosurea agent that contains a glucose moiety and interferes with DNA function; alkylates DNA, crosslinks DNA strands, ...
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streptozocin. Drug Summary. Classes. Nitrosoureas. Boxed Warning. Hypophosphatemia, nephrotoxicity, proteinuria, renal disease, renal failure, ...